merck millipore,默克密理愽
  • merck millipore,默克密理博,15-206,BACE Proteins Investigator Minipack

  • merck millipore,默克密理博,15-206,BACE Proteins Investigator Minipack

    产品名称：BACE Proteins Investigator Minipack
    产品型号：15-206
    This Antibody pack contains Anti-BACE Antibody, Anti-BACE2 Antibody, Anti-BACE Antibody C-terminus.

    merck millipore,默克密理博,15-206,BACE Proteins Investigator Minipack

  • 产品介绍
  • merck millipore,默克密理博,15-206,BACE Proteins Investigator Minipack

    描述
    产品目录编号 15-206
    描述 BACE Proteins Investigator Minipack
    Alternate Names
    • beta-site amyloid precursor protein cleaving enzyme 2 <br />transmembrane aspartic proteinase Asp2
    • ASP2
    • BACE1
    • Beta Secretase
    • beta-Site APP Cleaving Enzyme
    • Aspartyl protease 2
    • Beta-site amyloid precursor protein cleaving enzyme 1
    • Membrane-associated aspartic protease 2
    • beta-site amyloid beta A4 precursor protein-cleaving enzyme
    背景信息 Pathway Investigator Antibody MiniPack:
    Each Pathway Explorer Antibody Minipack contains three related antibodies as part of a signaling cascade or a combination of total and phosphorylated forms of key signaling targets. Each of the three antibodies are 30% the original pack size. Full size versions of each of the Pathway Explorer antibodies are available for sale individually under the same catalog number with the removal of “SP” off of each one (e.g. 05-591SP can be ordered as 05-591).

    Anti-BACE:
    BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational proteolytic cleavages and glycosylation. Sequence analysis has revealed that the immature form of BACE contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form by a signal peptidase located in the endoplasmic reticulum (ER), yielding the proBACE protein (Mr=75 kDa) which starts at residue 22. The proBACE protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE protein.

    Anti-BACE2:
    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer’s disease and a frequent complication of Down syndrome. BACE2 proteolytically cleaves amyloid precursor protein, generating the amyloid beta peptide. BACE2 is a member of the peptidase A1 protein family, a type I integral membrane glycoprotein and aspartic protease.

    Anti-BACE, C-terminus, clone 61-3E7:
    Alzheimer's disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid b-peptide (Ab). Ab generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Ab by b-secretase. The Ab peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. A human transmembrane aspartic-protease (Asp2), referred to as BACE, has been characterized and shown to have all the properties of b-secretase. Four groups in all have now confirmed that BACE (or Asp2) is a convincing candidate for b-secretase. BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational.

    * See full size versions for corresponding references.
    产品信息
    部件
    • MAB5308SP Anti-BACE, C-terminus, clone 61-3E7
    • AB5940SP Anti-BACE
    • AB9574SP Anti-BACE2
    演示 3 individual tubes containing either Anti-BACE; Anti-BACE2; or Anti-BACE, C-terminus, clone 61-3E7
    性质 Each vial is 30% the size of the parent catalog number
    应用
    应用 This Antibody pack contains Anti-BACE Antibody, Anti-BACE2 Antibody, Anti-BACE Antibody C-terminus.
    生物信息
    Entrez基因编号
    • NP_036237.2
    • AAH36084
    基因符号
    • beta-secretase
    • ASP2
    • BACE
    • EC 3.4.23.46
    • FLJ90568
    • HSPC104
    • KIAA1149
    • Memapsin-2
    UniProt编号
    • P56817
    • Q9Y5Z0
    UniProt汇总 BACE1:
    FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
    CATALYTIC ACTIVITY: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
    ENZYME REGULATION: Inhibited by RTN3 and RTN4.
    SUBUNIT: Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    ALTERNATIVE PRODUCTS: 4 named isoforms [FASTA] produced by alternative splicing.
    TISSUE SPECIFICITY: Brain.
    SIMILARITY: Belongs to the peptidase A1 family

    BACE2:
    CATALYTIC ACTIVITY: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
    SUBUNIT: Interacts ith RTN3 and RTN4.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: Belongs to the peptidase A1 family [view classification].
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 3 vials/Pk

    merck millipore,默克密理博,15-206,BACE Proteins Investigator Minipack

上一件merck millipore产品：merck millipore,默克密理博,AB5678P,Anti-Acid Sensitive Ion Channel 3 Antibody
下一件merck millipore产品：merck millipore,默克密理博,ABE472,Anti-WAC Antibody, NT


相关产品

merck millipore,默克密理博,AB3515,Anti-Adipocyte Fatty Acid Binding Protein Antibody merck millipore,默克密理博,AB3515,Anti-Adipocyte Fatty Acid Binding Protein Antibody

merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg merck millipore,默克密理博,14-507M,TrkB Recombinant Human Protein, Active, 250 µg

merck millipore,默克密理博,AP189F,Donkey Anti-Rat IgG Antibody, FITC conjugate, Species Adsorbed merck millipore,默克密理博,AP189F,Donkey Anti-Rat IgG Antibody, FITC conjugate, Species Adsorbed

merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

merck millipore,默克密理博,AB5678P,Anti-Acid Sensitive Ion Channel 3 Antibody merck millipore,默克密理博,AB5678P,Anti-Acid Sensitive Ion Channel 3 Antibody

merck millipore,默克密理博,ABE472,Anti-WAC Antibody, NT merck millipore,默克密理博,ABE472,Anti-WAC Antibody, NT

merck millipore,默克密理博,437644,Lipoproteins, Low Density, Human Plasma merck millipore,默克密理博,437644,Lipoproteins, Low Density, Human Plasma

merck millipore,默克密理博,14-461,IKKα Protein, active, 10 µg merck millipore,默克密理博,14-461,IKKα Protein, active, 10 µg

merck millipore,默克密理博,ABE38,Anti-HEN1 methyltransferase homolog 1 Antibody merck millipore,默克密理博,ABE38,Anti-HEN1 methyltransferase homolog 1 Antibody

merck millipore,默克密理博,MSFCN6B10,MultiScreenHTS FC，1.2/0.65 µm，不透明，非无菌 merck millipore,默克密理博,MSFCN6B10,MultiScreenHTS FC，1.2/0.65 µm，不透明，非无菌


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部