merck millipore,默克密理愽
  • merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

  • merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

    产品名称：Anti-DASM1 Antibody
    产品型号：AB15458
    Anti-DASM1 Antibody detects level of DASM1 & has been published & validated for use in WB.

    merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    RbWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15458
    描述 Anti-DASM1 Antibody
    Alternate Names
    • immunoglobulin superfamily, member 9
    • Immunoglobulin superfamily member 9A
    • immunoglobulin superfamily
    背景信息 Dasm1 contains five Ig domains and two fibronectin III domains in the extracellular N terminus, a single transmembrane domain, and an intracellular C-terminal tail with a type I PDZ domain binding motif at the end. It is highly expressed in the brain and localized at the dendrites. Suppression of Dasm1 expression in hippocampal neurons via RNA interference or expression of Dasm1 without its cytoplasmic tail specifically impairs dendrite, but not axon, outgrowth. Together with its orthologues in other species, Dasm1 defines a family of molecules likely involved specifically in dendrite arborization.
    产品信息
    格式 Affinity Purified
    控制
    • Western Blot: fetal (e14) mouse brain and fetal (e16) rat brain
    演示 Purified in PBS containing containing with 0.05% NaN3.
    应用
    应用 Anti-DASM1 Antibody detects level of DASM1 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis:
    Antibody detected DASM1 in 10 μg of fetal (e14) mouse brain.
    生物信息
    免疫原品种 Synthetic peptide corresponding to aa: 416-429 of human DASM1.
    表位 416-429
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The antibody reacts with the 130 kDa DASM1 protein.
    品种反应性 Rabbit
    Species Reactivity Note Reacts with human, mouse and rat. Other species have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001135050.1
    基因符号
    • OTTHUMP00000024411
    • FP18798
    • IGSF9A
    • KIAA1355
    • NRT1
    • Nrt1
    纯化方法 Antigen affinity purified
    UniProt编号
    • Q05BQ1
    UniProt汇总 FUNCTION: Functions in dendrite outgrowth and synapse maturation.
    SUBUNIT: Interacts with MAGI2 and SHANK1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse (By similarity). Note=Enriched at the excitatory synapses in mature neurons (By similarity).
    TISSUE SPECIFICITY: Expressed in both cell bodies and dendrites of cortical and hippocampal neurons and also cerebellar Purkinje cells (at protein level).
    DEVELOPMENTAL STAGE: Detected in brain during embryonic development at least from E7.5 until E16.5. Mainly expressed within the dorsal root glanglia, trigeminal glanglia and olfactory epithelium of E10.5 embryos. Expressed to a lower extent in neuroepithelium, retina and hindgut.
    DOMAIN: The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.
    SIMILARITY: Belongs to the immunoglobulin superfamily. Turtle family.
    SIMILARITY: Contains 2 fibronectin type-III domains.
    SIMILARITY: Contains 5 Ig-like (immunoglobulin-like) domains.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on fetal (e14) mouse brain cells lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB15458,Anti-DASM1 Antibody

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