merck millipore,默克密理愽
  • merck millipore,默克密理博,14-480M,Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

  • merck millipore,默克密理博,14-480M,Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

    产品名称：Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg
    产品型号：14-480M
    Active, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.

    merck millipore,默克密理博,14-480M,Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-480M,Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

    描述
    产品目录编号 14-480M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg
    概述 Recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 and Pro2
    应用
    应用 Active, recombinant human RSK2, full-length with an N-terminal His6 tag between Met1 & Pro2, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004586.2
    Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
    基因符号
    • ISPK-1
    • RPS6KA3
    • CLS
    • RSK-2
    • RSK2
    • p90-RSK2
    • ISPK1
    • MRX19
    • HU-3
    • pp90RSK2
    • MAPKAPK1B
    • HU-2
    • RSK
    • S6K-alpha3
    蛋白靶 Rsk2
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • P51812
    UniProt汇总 FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
    COFACTOR: Magnesium (By similarity).
    SIZE: 740 amino acids; 83736 Da
    SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
    TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
    PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
    DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
    SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
    产品使用声明
    质量保证 the MAPKAP Kinase 2 substrate peptide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -70C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-480) and in bulk (cat# 14-480-K).

    merck millipore,默克密理博,14-480M,Rsk2/MAPKAP Kinase 1b Protein, active, 250 µg

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