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品种反应性 主要应用 宿主 格式 抗体类型 Rb, B, H, M, R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-870 品牌系列 Upstate
商名 - Upstate
描述 Anti-PKCα, β, γ Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-PKCα Antibody, β, γ is validated for use in WB for the detection of PKCα. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide corresponding to amino acids 641-673 [TPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS] of the C-terminus of rabbit Protein Kinase C alpha, beta and gamma 宿主 Rabbit 特异性 Protein Kinase C alpha, beta and gamma isoforms 同种型 IgG 品种反应性 RabbitBovineHumanMouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002737.2
Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. 基因符号 - PKCA
- PRKCA
- PKC-A
- AAG6
- PKC-alpha
- MGC129901
- MGC129900
- PRKACA
纯化方法 Protein A chromatography UniProt编号 - P05129
- P17252
- P05771
UniProt汇总 FUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
SIZE: 672 amino acids; 76764 Da
SUBUNIT: Interacts with CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
SIMILARITY: SwissProt: P17252 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from bovine brain cytosol. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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