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merck millipore,默克密理博,14-331,SGK1 (δ1-59, S422D) Protein, active, 6 µg
产品名称：SGK1 (δ1-59, S422D) Protein, active, 6 µg
产品型号：14-331
Active, N-truncated (missing N-terminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation, for use in Kinase Assays.
merck millipore,默克密理博,14-331,SGK1 (δ1-59, S422D) Protein, active, 6 µg
- 产品介绍
描述 产品目录编号 14-331 品牌系列 Upstate
商名 - Upstate
描述 SGK1 (δ1-59, S422D) Protein, active, 6 µg 概述 N-truncated (missing Nterminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation 应用 应用 Active, N-truncated (missing N-terminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005627.2
Entrez基因汇总 This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition. 基因符号 - SGK1
- SGK
蛋白靶 SGK1 纯化方法 Ni-NTA agarose 靶子系列 AGC UniProt编号 - O00141
UniProt汇总 FUNCTION: SwissProt: O00141 # Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.
SIZE: 431 amino acids; 48942 Da
SUBUNIT: Interacts with NEDD4 and NEDD4L.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation.
TISSUE SPECIFICITY: Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung.
PTM: Regulated by phosphorylation. Phosphoinositide 3-kinase (PI3- kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1. & Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells.
SIMILARITY: SwissProt: O00141 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by Kinase assay 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -70°C 包装信息 数量 6 µg
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