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描述 产品目录编号 14-328 品牌系列 Upstate
商名 - Upstate
描述 JNK1α1/SAPK1c Protein, unactive, 50 µg 概述 N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c 应用 应用 Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_139049.1
- NM_002750.2
- NM_139046.1
- NM_139047.1
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. 基因符号 - JNK1A2
- MAPK8
- JNK1
- JNK21B1/2
- PRKM8
- JNK-46
- JNK
- SAPK1
蛋白靶 JNK1α1/SAPK1c 纯化方法 Ni2+/NTA-agarose 靶子系列 CMGC UniProt编号 - P45983
UniProt汇总 FUNCTION: SwissProt: P45983 # JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
COFACTOR: Magnesium.
SIZE: 427 amino acids; 48296 Da
SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP (By similarity).
DOMAIN: SwissProt: P45983 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by phosphorylation of ATF2 (amino acids 19-196) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -20°C 包装信息 数量 50 µg
上一件merck millipore产品：merck millipore,默克密理博,S24-100ML,Rat Serum
下一件merck millipore产品：merck millipore,默克密理博,499635,OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
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