merck millipore,默克密理愽
  • merck millipore,默克密理博,575546,Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem

  • merck millipore,默克密理博,575546,Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem

    产品名称：Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem
    产品型号：575546
    The Tankyrase1/2 Inhibitor III controls the biological activity of Tankyrase1/2.

    merck millipore,默克密理博,575546,Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,575546,Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₉N₅O₃S865565-29-4
    描述
    概述 A cell-permeable triazolylthiomethyl-oxadiazole compound that binds TNKS1/PARP5a and TNKS2/PARP5b with high affinity (Kd = 79 and 28 nM, respectively), and acts as a potent and reversible TNKS1/2 dual inhibitor (IC50 = 33 nM TNKS2 in an auto-PARsylation assay). Shown to interact with the adenosine diphosphate linker portion of the NAD+ donor site, and display excellent selectivity over PARP1 and PARP2 activities (IC50 > 19 µM); stabilize Axin2 levels (EC50 = 709 nM in SW480 cells), and antagonize Wnt signaling (IC50 = 215 nM in HEK293-SuperTopFlash assay). Exhibits minimal activity towards cytochrome P450 enzymes (IC50 = 21 and 5.7 µM for CYP2C9 and CYP3A4) and hERG ion channel (IC50 > 30 µM), and adequate microsomal stability.
    产品目录编号 575546
    品牌系列 Calbiochem®
    同义词 3-(4-Methoxyphenyl)-5-((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole, TNKS1/2 Inhibitor III, Wnt Pathway Inhibitor XIV
    参考
    参考 Shultz, M.D., et al. 2012. J. Med. Chem. 55, 1127.
    产品信息
    CAS号 865565-29-4
    形式 White solid
    Hill配方 C₂₀H₁₉N₅O₃S
    Molar Mass 409.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 TNKS1/PARP5a and TNKS2/PARP5b
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient or Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Avoid freeze/thaw cycles of solutions.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,575546,Tankyrase1/2 Inhibitor III - CAS 865565-29-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MACR81275,用于 12 mm x 75 mm 瓶的 MultiScreen 打孔器


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