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merck millipore,默克密理博,499635,OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
产品名称：OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
产品型号：499635
The OSC Inhibitor, Ro 48-8071, also referenced under CAS 189197-69-1, controls the biological activity of 2,3-oxidosqualene:lanosterol cyclase activity (OSC).
merck millipore,默克密理博,499635,OSC Inhibitor, Ro 48-8071 - CAS 189197-69-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₇BrFNO₂• C₄H₄O₄ 189197-69-1 描述 概述 An orally bioavailable benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 µM). 产品目录编号 499635 品牌系列 Calbiochem®
同义词 4ʹ-(6-(Allylmethylamino)hexyloxy)-4-bromo-2ʹ-fluorobenzophenone, fumarate 参考 参考 Thoma, R., et al. 2004. Nature 432, 118.
Peffley, D.M., et al. 1998. Biochem. Pharmacol. 56, 439.
Morand, O.H., et al. 1997. J. Lipid Res. 38, 373.产品信息 CAS号 189197-69-1 形式 Off-white solid Hill配方 C₂₃H₂₇BrFNO₂• C₄H₄O₄ 化学配方 C₂₃H₂₇BrFNO₂• C₄H₄O₄ Molar Mass 564.4 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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