merck millipore,默克密理愽
  • merck millipore,默克密理博,570250,STO-609 - CAS 52029-86-4 - Calbiochem

  • merck millipore,默克密理博,570250,STO-609 - CAS 52029-86-4 - Calbiochem

    产品名称：STO-609 - CAS 52029-86-4 - Calbiochem
    产品型号：570250
    A cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/CaM-KK.

    merck millipore,默克密理博,570250,STO-609 - CAS 52029-86-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,570250,STO-609 - CAS 52029-86-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₀N₂O₃ • CH₃CO₂H52029-86-4
    描述
    概述 A cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) [IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively]. Binds to the catalytic domain of CaM-KK, and inhibits autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 = ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC, and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK).
    产品目录编号 570250
    品牌系列 Calbiochem®
    同义词 7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate
    参考
    参考 Levine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
    Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
    Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813.
    产品信息
    CAS号 52029-86-4
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₉H₁₀N₂O₃ • CH₃CO₂H
    化学配方 C₁₉H₁₀N₂O₃ • CH₃CO₂H
    Molar Mass 374.4
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 CaM-KKα
    主靶IC50 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or 100 mM NaOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,570250,STO-609 - CAS 52029-86-4 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,SCGVU02RE,Stericup-GV，0.22 µm，PVDF，250 mL，射线灭菌


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