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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABN55 描述 Anti-Netrin-1 Antibody Alternate Names - Ntn1
- netrin 1, mouse, homolog of
- Netrin 1
背景信息 Netrin-1 is a secreted, bifunctional ligand belonging to the Netrin family; a group of proteins known to act as versatile, chemotropic axon guidance cues for CNS commissural and peripheral motor axons. Netrin-1 is necessary for spinal cord oligodendrocyte development. There are two receptors with which Netrin-1 is associated and that will cause it to be either a chemoattractant or a chemorepellant for axons. Receptor Deleted in Colorectal Cancer (DCC) regulates the attraction of axons to Netrin-1, and UNC5 mediates axon repulsion from Netrin-1. Studies have shown Netrin-1 to function as a survival factor through its relationship to its receptors, inhibiting the onset of apoptosis. Netrin-1 has also been implicated in colorectal tumorigenesis via its apoptotic regulatory role. Expression of Netrin-1 has been detected in adult axons and oligodendrocytes, and is also widely observed in developing embryonic mesodermal tissues and nervous system. 产品信息 格式 Serum 控制 - Mouse brain tissue lysate
演示 Rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-Netrin-1 Antibody detects level of Netrin-1 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Linear peptide corresponding to mouse Netrin-1. 表位 Unknown 宿主 Rabbit 同种型 IgG 品种反应性 RatMouse Species Reactivity Note Demonstrated to react with mouse and rat. Other homologies: Human (94% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_032770
基因符号 - NTN1L
- NTN1
纯化方法 Unpurified UniProt编号 - O09118
UniProt汇总 FUNCTION: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity).
SUBUNIT STRUCTURE: Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Binds to its receptor; DSCAM.
SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix
TISSUE SPECIFICTY: In the embryo, widely expressed in the developing nervous system and in mesodermal tissues.
SEQUENCE SIMILARITIES: Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.
Contains 1 NTR domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 1:10,000 dilution of this antibody detected Netrin-1 on 10 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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