merck millipore,默克密理愽
  • merck millipore,默克密理博,128136,7α, 25-dihydroxycholesterol - Calbiochem

  • merck millipore,默克密理博,128136,7α, 25-dihydroxycholesterol - Calbiochem

    产品名称：7α, 25-dihydroxycholesterol - Calbiochem
    产品型号：128136


    merck millipore,默克密理博,128136,7α, 25-dihydroxycholesterol - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,128136,7α, 25-dihydroxycholesterol - Calbiochem

    重要规格表

    经验配方
    C₂₇H₄₆O₃
    描述
    概述 A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450 pM in a saturation binding analysis, and activates EBI2 (EC50=140 pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-γ assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-β galactosidase cell line with an IC50 of 2 nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice.
    产品目录编号 128136
    品牌系列 Calbiochem®
    同义词 EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC
    参考
    参考 Liu, C., et al. 2011. Nature 475, 519.
    产品信息
    形式 White powder
    Hill配方 C₂₇H₄₆O₃
    化学配方 C₂₇H₄₆O₃
    Molar Mass 418.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,128136,7α, 25-dihydroxycholesterol - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,557502,Ro-20-1724 - CAS 29925-17-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,0500-3115,Muse Cell Analyzer


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