merck millipore,默克密理愽
  • merck millipore,默克密理博,100069,17-DMAG - CAS 467214-21-7 - Calbiochem

  • merck millipore,默克密理博,100069,17-DMAG - CAS 467214-21-7 - Calbiochem

    产品名称：17-DMAG - CAS 467214-21-7 - Calbiochem
    产品型号：100069
    A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.

    merck millipore,默克密理博,100069,17-DMAG - CAS 467214-21-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,100069,17-DMAG - CAS 467214-21-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₂H₄₈N₄O₈ • HCl467214-21-7
    描述
    概述 A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
    产品目录编号 100069
    品牌系列 Calbiochem®
    同义词 NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
    参考
    参考 Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
    Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
    Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
    产品信息
    CAS号 467214-21-7
    具有ATP竞争性 N
    形式 Purple solid
    Hill配方 C₃₂H₄₈N₄O₈ • HCl
    化学配方 C₃₂H₄₈N₄O₈ • HCl
    Molar Mass 653.2
    可逆 N
    结构配方图像
    生物信息
    主靶 17-DMAG
    主靶IC50 GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
    纯度 ≥95% by TLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,100069,17-DMAG - CAS 467214-21-7 - Calbiochem

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