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merck millipore,默克密理博,09-816,Anti-JMJD1B Antibody
产品名称：Anti-JMJD1B Antibody
产品型号：09-816
Anti-JMJD1B Antibody is a rabbit polyclonal antibody for detection of JMJD1B also known as Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, chromosome 5 open reading frame 7 & has been val More>>
merck millipore,默克密理博,09-816,Anti-JMJD1B Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Eq, H, M, R, Rb, Rhesus Macaque ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-816 描述 Anti-JMJD1B Antibody Alternate Names - jumonji domain containing 1B
- JMJD
- Jumonji domain-containing protein 1B
- Nuclear protein 5qNCA
- chromosome 5 open reading frame 7
背景信息 Methylation of histones plays a critical role in regulating chromatin structure and transcription. The JMJD1 (Jumonji domain-containing protein 1) family, also known as JHDM2 (JmjC domain-containing histone demethylation protein 2) family, contains four members: hairless (HR), JMJD1A/JHDM2A, JMJD1B/JHDM2B, and JMJD1C/JHDM2C. JMJD1B has been shown to specifically demethylate mono-methyl and di-methyl histone H3 on lysine9. H3 Lys 9 methylation is a highly studied histone mark that represses gene expression and implicates JMJD1B as a key regulator of heterochromatin assembly. Deletions in the gene encoding JMJD1B are frequently associated with myeloid leukemias and myelodysplasias, suggesting JMJD1B also may act as a tumor suppressor. 产品信息 格式 Affinity Purified 控制 - HeLa nuclear extract
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-JMJD1B Antibody is a rabbit polyclonal antibody for detection of JMJD1B also known as Jumonji domain-containing protein 1B, Nuclear protein 5qNCA, chromosome 5 open reading frame 7 & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1B in HeLa cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human JMJD1B. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HorseHumanMouseRatRabbitRhesus Macaque Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse, Rat, Rabbit, Rhesus Macaque, and Equine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_057688
基因符号 - JMJD1B
- 5qNCA
- JHDM2B
- KDM3B
纯化方法 Affinity purified UniProt编号 - Q7LBC6
UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICTY: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).
MISCELLANEOUS: Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.
SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.
SEQUENCE CAUTION: The sequence BAA83034.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by Western Blot in HeLa nuclear extract.
Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1B on 10 µg of HeLa nuclear extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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