- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,04-1582,Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6
产品名称：Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6
产品型号：04-1582
Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6 detects level of Interleukin 23 (IL-23) p40 & has been published & validated for use in WB.
merck millipore,默克密理博,04-1582,Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 04-1582 描述 Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6 Alternate Names - IL-23 subunit alpha
- interleukin 23, alpha subunit p19
- interleukin 23 p19 subunit
- interleukin-23 subunit alpha
- Interleukin-23 subunit p19
- JKA3 induced upon T-cell activation
背景信息 Interleukin-23 (IL-23) is a heterodimer, the combination of IL-23-specific subunit p19 and IL-12 subunit p40 comprise the biologically active protein. Like IL-12, IL-23 has been shown to activate the transcription factor STAT4 (signal transducer and activator of transcription-4). Unlike IL-12, IL-23 also seems to play a role in the signaling of memory T cells. IL-23, in conjunction with IL-17, is important in controlling the bacterial growth and inflammation response in an organism with tuberculosis. It has the ability to induce Th17 activation and stimulate inflammation in many tissue types including periodontal lesions. 产品信息 格式 Purified 控制 - Human IL-23 recombinant protein
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Interleukin 23 (IL-23) p40 Antibody, clone 2G6 detects level of Interleukin 23 (IL-23) p40 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full length cohesin-tagged recombinant protein corresponding to human IL-23 protein. 克隆 AB54.69.3G2.1D9 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody specifically recognizes the p40 subunit of IL-23. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002178
Entrez基因汇总 This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq]. 基因符号 - IL-23
- IL-23-A
- SGRF
- IL-23p19
- IL23P19
- P19
- IL-23A
纯化方法 Protein G UniProt编号 - P29460
UniProt汇总 FUNCTION: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
SUBUNIT STRUCTURE: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
SUBCELLULAR LOCATION: Secreted.
PTM: Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
INVOLVEMENT IN DISEASE: Defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 3 subfamily.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by Western Blot in human IL-23 recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-23 on 10 µg of human IL-23 recombinant protein.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,CBL251,Anti-Epithelial Specific Antigen Antibody, clone VU-1D9
下一件merck millipore产品：merck millipore,默克密理博,09-180,Anti-IGFBP-3 Antibody
相关产品
merck millipore,默克密理博,EZCL-31K,Canine Leptin ELISA
merck millipore,默克密理博,04-467,Anti-phospho-LAT (Tyr191) Antibody, rabbit monoclonal
merck millipore,默克密理博,09-816,Anti-JMJD1B Antibody
merck millipore,默克密理博,CBL251,Anti-Epithelial Specific Antigen Antibody, clone VU-1D9
merck millipore,默克密理博,09-180,Anti-IGFBP-3 Antibody
merck millipore,默克密理博,HTS016RTA,Ready-to-Assay™ C3a Anaphylotoxin Receptor Frozen Cells
merck millipore,默克密理博,444248,MMP-13, Proenzyme, His•Tag, Human, Recombinant, S. frugiperda
merck millipore,默克密理博,70191,pSTBlue-1 Perfectly Blunt Cloning Kit - Novagen
merck millipore,默克密理博,538904,Prostaglandin E₂ - CAS 363-24-6 - Calbiochem