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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 09-180 品牌系列 Upstate
商名 - Upstate
描述 Anti-IGFBP-3 Antibody Alternate Names - acid stable subunit of the 140 K IGF complex
- Insulin-like Growth Factor Binding Protein 3, IGF-binding protein 3
- IGF-binding protein 3
产品信息 格式 Purified 应用 应用 Detect IGFBP-3 using this Anti-IGFBP-3 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH conjugated synthetic peptide corresponding to the C-terminus of rat IGFBP-3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes IGFBP-3 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001013398.1
- NM_000598.4
Entrez基因汇总 This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. 基因符号 - BP-53
- IGFBP3
- IBP3
- IGFBP-3
纯化方法 Protein G purfied UniProt编号 - P17936
UniProt汇总 FUNCTION: SwissProt: P17936 # IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
SIZE: 291 amino acids; 31674 Da
SUBUNIT: Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by most tissues.
DEVELOPMENTAL STAGE: IGFBP3 levels are higher during extrauterine life and peak during puberty.
DOMAIN: SwissProt: P17936 The thyroglobulin type-1 domain mediates interaction with HN.
SIMILARITY: Contains 1 IGFBP N-terminal domain. & Contains 1 thyroglobulin type-1 domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at 4°C from date of shipment 包装信息 数量 100 µL
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