merck millipore,默克密理愽
  • merck millipore,默克密理博,09-142,Anti-phospho-ACK1 (Tyr284) Antibody

  • merck millipore,默克密理博,09-142,Anti-phospho-ACK1 (Tyr284) Antibody

    产品名称：Anti-phospho-ACK1 (Tyr284) Antibody
    产品型号：09-142
    Detect phospho-ACK1 (Tyr284) using this Anti-phospho-ACK1 (Tyr284) Antibody validated for use in WB.

    merck millipore,默克密理博,09-142,Anti-phospho-ACK1 (Tyr284) Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-142,Anti-phospho-ACK1 (Tyr284) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 09-142
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-ACK1 (Tyr284) Antibody
    Alternate Names
    • TNK2, tyrosine kinase non-receptor 2, p21cdc42Hs, activated Cdc42-associated kinase 1, activated p21cdc42Hs kinase
    • TNK2
    • tyrosine kinase non-receptor 2
    • p21cdc42Hs
    • activated Cdc42-associated kinase 1
    产品信息
    格式 Affinity Purified
    控制
    • Brain tissue
    演示 Immunoaffinity Purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride (pH 7.6) containing 0.1% sodium azide and 30% glycerol.
    应用
    应用 Detect phospho-ACK1 (Tyr284) using this Anti-phospho-ACK1 (Tyr284) Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH conjugated synthetic peptide corresponding to amino acids surrounding Tyr 284 of human ACK1.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes ACK1 phosphorylated on Tyrosine residue 284.
    同种型 IgG
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005781.4
    • NM_001010938.1
    Entrez基因汇总 This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
    基因符号
    • ACK
    • TNK2
    • p21cdc42Hs
    • ACK1
    • ACK-1
    • FLJ45547
    • FLJ44758
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q07912
    UniProt汇总 FUNCTION: SwissProt: Q07912 # Downstream effector of CDC42 which mediates CDC42- dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
    COFACTOR: Magnesium.
    SIZE: 1036 amino acids; 114327 Da
    SUBUNIT: Interacts with CDC42. Interacts with activated CSPG4.
    SUBCELLULAR LOCATION: Cell membrane (By similarity).
    SIMILARITY: SwissProt: Q07912 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,09-142,Anti-phospho-ACK1 (Tyr284) Antibody

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