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品种反应性 主要应用 宿主 格式 抗体类型 H WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 09-126 品牌系列 Upstate
商名 - Upstate
描述 Anti-Tribbles-1 Antibody 背景信息 The Tribbles family of proteins are kinase-like proteins that contain a kinase-like domain, but lack either a catalytic domain or a protein-protein interaction domain (2). They are believed to regulate signal processing for various pathways including MAPK, Akt, and NFkB that are involved in various aspects of development, diabetes, and cancer (1,2,3). Their involvement has been reported to regulate a number of pathways that include mitosis, cell activation, and apoptosis. They are are a family made up of three family members. Tribbles-1 (TRIB1, SKIP1, G-protein-coupled receptor induced protein, and phosphoprotein regulated by mitogenic pathways) is a modulator of MAPK action. It has been shown to directly interact with the upstream kinases MEK1 and MKK4 of Erk and JNK, respectively(1). Tribble-2 (Trib2, TRB2) has been shown to interact with Akt(2). Tribbles-3 (TRIB3, TRB3. NIPK, SKIP3) has been shown to interact with Akt and the transcription factors ATF4 and NFkB p65 (RelA). It is interaction with RelA is thought to be negative regulation. Interestingly, it has been reported to regulate Akt activation via insulin(3). 产品信息 格式 Affinity Purified 控制 - HeLa
演示 100 μg in 100μL of affinity purified rabbit serum in storage buffer containing PBS with 0.05% sodium azide. 应用 应用 This Anti-Tribbles-1 Antibody is validated for use in IH, WB for the detection of Tribbles-1. 主要应用 - Western Blotting
- Immunohistochemistry
生物信息 免疫原品种 KLH-conjugated sythetic linear peptide directed against a region of the N-terminal portion of Tribbles-1. 表位 N-terminal 宿主 Rabbit 特异性 Tribbles-1 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_079471
基因符号 - GIG2
- TRIB1
- TRB1
- SKIP1
- C8FW
纯化方法 Affinity Purfied UniProt编号 - Q96RU8
产品使用声明 质量保证 routinely evaluated by western blot on lysate from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,05-621,Anti-CUGBP1 Antibody, clone 3B1
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