merck millipore,默克密理博,07-852,Anti-phospho-MEK1 (Thr292) Antibody

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merck millipore,默克密理博,07-852,Anti-phospho-MEK1 (Thr292) Antibody
产品名称：Anti-phospho-MEK1 (Thr292) Antibody
产品型号：07-852
Anti-phospho-MEK1 (Thr292) Antibody is an antibody against phospho-MEK1 (Thr292) for use in WB.

merck millipore,默克密理博,07-852,Anti-phospho-MEK1 (Thr292) Antibody

产品介绍

merck millipore,默克密理博,07-852,Anti-phospho-MEK1 (Thr292) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-852
Replaces	07-348
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-MEK1 (Thr292) Antibody
Alternate Names	MAP2K1 MAP Kinase Kinase 1 MAPK/ERK Kinase 1 MAPKK1

产品信息
格式	Affinity Purified
演示	100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.

应用
应用	Anti-phospho-MEK1 (Thr292) Antibody is an antibody against phospho-MEK1 (Thr292) for use in WB.
主要应用	Western Blotting
应用说明	Immunoblot Analysis: A 1:1000 dilution of this lot detected phosphorylated MEK1 (Thr292) in RIPA lysates of untreated A431 cells.

生物信息
免疫原品种	Peptide corresponding to amino acid region encompassing the human, mouse, rat and hamster phospho-MEK1 (Thr292).
宿主	Rabbit
特异性	Recognizes phospho-MEK1 (Thr292).
同种型	IgG
品种反应性	MouseHuman
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_002755.2
Entrez基因汇总	The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
基因符号	MKK1 MAP2K1 MAPKK1 PRKMK1 MEK1
修改	Phosphorylation
纯化方法	Immunoaffinity purified
UniProt编号	Q02750
UniProt汇总	FUNCTION: SwissProt: Q02750 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases. SIZE: 393 amino acids; 43439 Da SUBUNIT: Interacts with MORG1 (By similarity). Interacts with Yersinia yopJ. PTM: Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. & Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. DISEASE: SwissProt: Q02750 # Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. SIMILARITY: SwissProt: Q02750 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.