merck millipore,默克密理愽
  • merck millipore,默克密理博,07-722,Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

  • merck millipore,默克密理博,07-722,Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

    产品名称：Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody
    产品型号：07-722
    Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody is an antibody against phospho-VEGFR2/Flk-1/KDR (Tyr1054) for use in WB.

    merck millipore,默克密理博,07-722,Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-722,Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Zebrafish, H, M, R, Pm, B, Ch, EqWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-722
    商名
    • Upstate
    描述 Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody
    Alternate Names
    • vascular endothelial growth factor receptor 2
    • Kinase insert domain receptor
    • Protein-tyrosine kinase receptor Flk-1
    • kinase insert domain receptor (a type III receptor tyrosine kinase)
    背景信息 The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 (also known as Flk-2) is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines.
    产品信息
    格式 Affinity Purified
    控制
    • CSF-1 treated PAE cell lysate, transfected with CSF/KDR.
    演示 Affinity purified rabbit polyclonal IgG in PBS with 0.05% NaN3 and 50% glycerol.
    应用
    应用 Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody is an antibody against phospho-VEGFR2/Flk-1/KDR (Tyr1054) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic peptide encompassing
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes VEGFR2/Flk-1/KDR when phosphorylated on Tyrosine 1054 (human).
    品种反应性 ZebrafishHumanMouseRatPrimateBovineChickenHorse
    Species Reactivity Note Human tested. Expected to react with Mouse, Rat, primate, cow, chicken, horse, and Danio based on 100% sequnce homolgy.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002253.2
    基因符号
    • EC 2.7.10.1
    • KDR
    • VEGFR-2
    • VEGFR2
    • VEGFR
    • CD309
    • FLK1
    修改
    • Phosphorylation
    纯化方法 Double affinity purified
    UniProt编号
    • P35968
    UniProt汇总 FUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1356 amino acids; 151527 Da
    SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. ...
    产品使用声明
    质量保证 Western Blot Analysis:
    This lot detected VEGFR2 phosphorylated on Tyr1054 at a 1:1,000 dilution in PAE cells transfected with CSF/KDR and treated with 40ng/mL CSF-1 for 15 min. Cell lysate resolved via SDS-PAGE and transferred to PVDF (Immobilon-P).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-722,Anti-phospho-VEGFR2/Flk-1/KDR (Tyr1054) Antibody

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