merck millipore,默克密理博,557366,Rosiglitazone - CAS 155141-29-0

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merck millipore,默克密理博,557366,Rosiglitazone - CAS 155141-29-0 - Calbiochem
产品名称：Rosiglitazone - CAS 155141-29-0 - Calbiochem
产品型号：557366
A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-γ (PPARγ) (Kd ~40 nM) in fat cells.

merck millipore,默克密理博,557366,Rosiglitazone - CAS 155141-29-0 - Calbiochem

产品介绍

merck millipore,默克密理博,557366,Rosiglitazone - CAS 155141-29-0 - Calbiochem

重要规格表

经验配方	CAS号
C₁₈H₁₉N₃O₃S.C₄H₄O₄	155141-29-0

描述
概述	A thiazolidinedione compound that acts as an anti-diabetic agent and serves as a potent and selective agonist of peroxisome proliferator-activated receptor-g (PPARg) (K_d ~40 nM) in fat cells. Shown to reduce fatty acid uptake and ameliorate lipid metabolism and insulin resistance in animal models of type II diabetes. Reported to activate both a1- and a2-containing AMPK complexes. Unlike troglitazone, it does not induce the activity of P4503A4. Significantly improves the differentiation of C3H10T1/2 stem cells into adipocytes. Shown to block estrogen synthesis by interfering with androgen binding to aromatase, but without affecting aromatase mRNA or protein expression.
产品目录编号	557366
品牌系列	Calbiochem®
同义词	5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione, BRL49653, Avandia, AMPK Signaling Activator X, PPAR Agonist X, PPARγ Agonist IX

参考
参考	Araki, T., et al. 2011. PPAR Res. 2011, 926438. Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739. Gerstein, H., et al. 2006. Drug 368, 9541. Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735. Fryer, L., et al. 2002. J Biol Chem 277, 25226. Goldberg, R., et al. 1999. Drug. 57, 921. Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751. Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953. Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.

参考

Araki, T., et al. 2011. PPAR Res. 2011, 926438.
Sozio, M. S., et al. 2011. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G739.
Gerstein, H., et al. 2006. Drug 368, 9541.
Mohanty, P., 2004. Journ. Clin. Endocrin. & Metab. 89(6), 2728-2735.
Fryer, L., et al. 2002. J Biol Chem 277, 25226.
Goldberg, R., et al. 1999. Drug. 57, 921.
Young, P., et al. 1998. Journ. Pharm. Exp. Ther. 284, 751.
Willson, T., et al. 1996. J. Med. Chem.39, 665; Lehmann, J., et al., 1995. JBC 270, 12953.
Cantello, B., et al., 1994. Bioorg. Med. Chem. Lett. 4, 1181.

产品信息
CAS号	155141-29-0
形式	White powder
Hill配方	C₁₈H₁₉N₃O₃S.C₄H₄O₄
化学配方	C₁₈H₁₉N₃O₃S.C₄H₄O₄
Molar Mass	473.5
结构配方图像

生物信息
纯度	≥99% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.