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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-648 Replaces 04-1037 品牌系列 Upstate
商名 - Upstate
描述 Anti-Aurora A Antibody 产品信息 格式 Purified 应用 应用 Detect Aurora A with Anti-Aurora A Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 6His-tagged fusion protein corresponding to full length human Aurora A 宿主 Rabbit 特异性 Aurora A 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_003600
Entrez基因汇总 The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. 基因符号 - STK6
- AURKA
- STK7
- AURA
- AIK
- hARK1
- BTAK
- AURORA2
- aurora-A
- Aurora-A
- STK15
- AurA
- ARK1
- MGC34538
纯化方法 Protein A purfied UniProt编号 - O14965
UniProt汇总 FUNCTION: SwissProt: O14965 # May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression.
SIZE: 403 amino acids; 45809 Da
SUBUNIT: Interacts with TACC1 and CPEB1. Interacts with and phosphorylates BORA.
SUBCELLULAR LOCATION: Centrosome. Spindle. Note=Localizes on centrosomes in interphase cells and at each spindle pole in mitosis.
TISSUE SPECIFICITY: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE:SwissProt: O14965 # Defects in AURKA are responsible for numerical centrosome aberrations including aneuploidy.
SIMILARITY: SwissProt: O14965 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 Routinely evaluated by immunoblot of untreated and colcemid treated HCT116 cell lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 200 µL
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