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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB, ICC Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15410 Replaces MABC135 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-APG12 Antibody Alternate Names - Autophagy-related protein 12, APG12-like, ATG12
- Autophagy-related protein 12
- APG12-like
背景信息 Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. The APG12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. APG12 conjugation of APG5 is required for elongation of the isolation membrane to form a complete spherical autophagosome. Discovery of the APG12 system has facilitated our understanding of the molecular mechanism of autophagosome formation. 产品信息 格式 Serum 演示 Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative. 应用 应用 Anti-APG12 Antibody is an antibody against APG12 for use in WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
应用说明 Western blot: 1:200-1:1,000
Immunocytochemistry: 1:200-1:1,000
Immunohistochemistry: 1:200-1:1,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to a region within the N-terminus of human APG12 protein. 宿主 Rabbit 特异性 APG12 [Autophagy-related protein 12, APG12-like, ATG12]. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004707.2
Entrez基因汇总 Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM] 基因符号 - APG12
- ATG12
- APG12L
- APG12-like
- HAPG12
纯化方法 Serum UniProt编号 - O94817
UniProt汇总 FUNCTION: SwissProt: O94817 # Required for autophagy.
SIZE: 140 amino acids; 15113 Da
SUBUNIT: Conjugated to ATG5.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: O94817 ## Belongs to the ATG12 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability. 包装信息 数量 50 µL
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