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  • merck millipore,默克密理博,07-608,Anti-dimethyl Histone H3 (Lys23) Antibody

  • merck millipore,默克密理博,07-608,Anti-dimethyl Histone H3 (Lys23) Antibody

    产品名称：Anti-dimethyl Histone H3 (Lys23) Antibody
    产品型号：07-608
    Use Anti-dimethyl Histone H3 (Lys23) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB, Mplex to detect dimethyl Histone H3 (Lys23) also known as H3K23me2, Histone H3 (di methyl K23).

    merck millipore,默克密理博,07-608,Anti-dimethyl Histone H3 (Lys23) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-608,Anti-dimethyl Histone H3 (Lys23) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-608
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-dimethyl Histone H3 (Lys23) Antibody
    Alternate Names
    • Histone H3 (di methyl K23)
    • H3K23me2
    产品信息
    格式 Affinity Purified
    演示 0.2M Tris-glycine, pH 7.4, 0.15M NaCl and 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Use Anti-dimethyl Histone H3 (Lys23) Antibody (Rabbit Polyclonal Antibody) validated in WB, DB, Mplex to detect dimethyl Histone H3 (Lys23) also known as H3K23me2, Histone H3 (di methyl K23).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide containing the sequence ATdimKAA corresponding to dimethylated lysine 23 of human histone H3.
    宿主 Rabbit
    特异性 dimethyl Histone H3 (Lys23)
    同种型 IgG1
    品种反应性 Human
    Species Reactivity Note Broad species cross-reactivity is expected
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003493
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
    基因符号
    • H3F3B
    • H3F3A
    • MGC87783
    • H3.3A
    • MGC87782
    • H3F3
    • H3.3B
    修改
    • Methylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q16695
    UniProt汇总 FUNCTION: SwissProt: Q16695 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    SIZE: 136 amino acids; 15508 Da
    SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Acetylation is generally linked to gene activation. Acetylation on Lys-10 impairs methylation at Arg-9. Acetylation on Lys-19 and Lys-24 favors methylation at Arg-18 (By similarity). & Citrullination at Arg-9 and/or Arg-18 by PADI4 impairs methylation and represses transcription (By similarity). & Asymmetric dimethylation at Arg-18 by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 by PRMT5 is linked to gene repression (By similarity). & Methylation at Lys-5, Lys-37 and Lys-80 are linked to gene activation. Methylation at Lys-5 facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 and Lys-28 are linked to gene repression. Methylation at Lys-10 is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 and acetylation of H3 and H4. Methylation at Lys-5 and Lys-80 require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 and Lys-28 are enriched in inactive X chromosome chromatin (By similarity). & Phosphorylated at Thr-4 by GSG2/haspin during prophase and dephosphorylated during anaphase. At centromeres, specifically phosphorylated at Thr-12 from prophase to early anaphase. Phosphorylated at Ser-11 during the whole mitosis. Phosphorylation at Ser-11, which is linked to gene activation, prevents methylation at Lys-10 but facilitates acetylation of H3 and H4. Phosphorylated at Ser-29 by MLTK isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation (By similarity). & Phosphorylation at 'Ser-11' is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at 'Ser-11' is important during interphase because it enables the transcription of genes following external stimulation, like stress or growth factors. Phosphorylation at 'Ser-11' is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylation at 'Ser-11' by AURKB/Aurora-B mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. & Ubiquitinated (By similarity).
    SIMILARITY: SwissProt: Q16695 ## Belongs to the histone H3 family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on acid extracted proteins from HeLa cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-608,Anti-dimethyl Histone H3 (Lys23) Antibody

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