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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-571-I Replaces 07-571 描述 Anti-nNOS/NOS I Antibody Alternate Names - Peptidyl-cysteine S-nitrosylase NOS1
- Nitric oxide synthase, brain
- BNOS
- Constitutive NOS
- NC-NOS
- NOS type I
- Neuronal NOS
- N-NOS
- nNOS
背景信息 Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. nNOS/NOS I, also known as NC-NOS, or NOS type I, or Neuronal NOS, or Peptidyl-cysteine S-nitrosylase NOS1 and bNOS produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. NOS I has been suggested to have nitrosylase activity and to mediate cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2). 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-nNOS/NOS I Antibody is an antibody against nNOS/NOS I for use in western blotting & IHC (Paraffin). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected nNOS/NOS I in rat cerebellum and cerebral cortex tissues, and mouse hippocampus and thalamus tissues. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the near N-terminus of rat nNOS/NOS I. 表位 Near N-terminus 浓缩 0.5 mg/mL 宿主 Rabbit 品种反应性 MouseRat 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_434686
基因符号 - Bnos
- Nos1
纯化方法 Affinity purified UniProt编号 - P29476
产品使用声明 质量保证 Evaluated by Western Blotting in rat brain microsomal preparation.
Western Blotting Analysis: A 1:500 dilution of this antibody detected nNOS/NOS I in 10 µg of rat brain microsomal preparation.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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