merck millipore,默克密理博,07-466,Anti-PPARγ Antibody

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merck millipore,默克密理博,07-466,Anti-PPARγ Antibody
产品名称：Anti-PPARγ Antibody
产品型号：07-466
Use Anti-PPARγ Antibody (Rabbit Polyclonal Antibody) validated in WB to detect PPARγ also known as Nuclear receptor subfamily 1 group C member 1, peroxisome proliferator activated receptor alpha.

merck millipore,默克密理博,07-466,Anti-PPARγ Antibody

产品介绍

merck millipore,默克密理博,07-466,Anti-PPARγ Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M, Vrt, Po, Rb, Rhesus Macaque, Mi	WB	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	07-466
品牌系列	Upstate
商名	Upstate
描述	Anti-PPARγ Antibody
Alternate Names	peroxisome proliferator-activated receptor gamma peroxisome proliferative activated receptor, gamma peroxisome proliferator activated receptor gamma peroxisome proliferator activated receptor gamma
背景信息	Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes where it regulates the expression of proteins involved in fatty acid metabolism. PPARβ is the most widely distributed subtype and is often expressed at high levels. PPARγ is predominantly seen in adipose tissue where it plays a critical role in regulating adipocyte differentiation.

产品信息
格式	Purified
控制	Human breast carcinoma tissue, rat skeletal muscle extract or U-937 cell lysate.
演示	Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide and 30% glycerol.

应用
应用	Use Anti-PPARγ Antibody (Rabbit Polyclonal Antibody) validated in WB to detect PPARγ also known as Nuclear receptor subfamily 1 group C member 1, peroxisome proliferator activated receptor alpha.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated, synthetic peptide (GEDKIKFKHITPLQEQ) corresponding to amino acids 256-271 of human PPARγ1 and amino acids 287-302 of human PPARγ2. The immunizing sequence is identical in mouse and rat.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Recognizes PPARγ1 and 2, Mr 55-60 kDa. A non-specific protein was also detected, Mr 47 kDa after longer exposure.
同种型	IgG
品种反应性	RatHumanMouseVertebratesPigRabbitRhesus MacaqueMink
Species Reactivity Note	Human and mouse. Predicted to cross-react with rat, pig, rabbit, rhesus monkey, mink and other vertebrates based on sequence conservation.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_005028.4
Entrez基因汇总	Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
基因符号	PPAR-gamma PPARG PPAR hPPAR
纯化方法	Protein A purfied
UniProt编号	Q53EW1
UniProt汇总	FUNCTION: SwissProt: Q07869 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. SIZE: 468 amino acids; 52225 Da SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Skeletal muscle, liver, heart and kidney. SIMILARITY: SwissProt: Q07869 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.

产品使用声明
质量保证	Evaluated by western blot in RIPA lysates from 3T3/L1 cells differentiated into adipocytes. Western Blot Analysis: 1-5 μg/mL of this antibody detected PPARγ protein in RIPA lysates from 3T3/L1 cells differentiated into adipocytes but not in undifferentiated 3T3/L1 cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt.

包装信息
数量	200 µg

merck millipore,默克密理博,07-466,Anti-PPARγ Antibody

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