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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-2264 描述 Anti-OSR1 Antibody Alternate Names - Oxidative stress-responsive 1 protein
- oxidative-stress responsive 1
- serine/threonine-protein kinase OSR1
背景信息 Odd-skipped-related protein 1 (OSR1) is expressed during the beginning stages of embryogenesis in the intermediate mesoderm and in patterns during limb and branchial arch development. It has been shown that OSR1 plays a critical part in creating kidney precursor cells and regulating differentiation into kidney tubular tissue. OSR1 may play a role in limiting endoderm differentiation from mesendoderm. Expression of OSR1 is controlled by Runx2 and Ikzf1 and is key in development of embryonic, heart and urogenital tissue. 产品信息 格式 Affinity Purified 控制 - HEK293 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect the OSR1 protein using this Anti-OSR1 validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human OSR1. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human and mouse. Other homologies: Rat (96% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005100
Entrez基因汇总 The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq]. 基因符号 - OXSR1
- OSR1
纯化方法 Affinity purified UniProt编号 - O95747
UniProt汇总 FUNCTION: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: By autophosphorylation on threonine.
SUBUNIT STRUCTURE: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. UniProtKB Q6P9R2
TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.
SEQUENCE CAUTION: The sequence AAP97192.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA83053.2 differs from that shown. Reason: Frameshift at position 63.产品使用声明 质量保证 Evaluated by Western Blot in HEK293 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected OSR1 on 10 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,04-236,Anti-Nibrin/NBS1 Antibody, clone Y112, rabbit monoclonal
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