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merck millipore,默克密理博,553590,InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem
产品名称：InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem
产品型号：553590
A cell-permeable polyketide that displays potent antitumor properties in eukaryotes.
merck millipore,默克密理博,553590,InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₈H₄₀O₅ 163564-92-9 描述 概述 A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase. 产品目录编号 553590 品牌系列 Calbiochem®
同义词 Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II 参考 参考 Köster, M., et al. 2003. Exp. Cell Res. 286, 321.
Kalesse, M., et al. 2001. Chem biochem 2, 709.
Gerth, K., et al. 1995. J. Antibiot. 48, 973.产品信息 CAS号 163564-92-9 具有ATP竞争性 N 形式 Liquid 配方 A 5 µg/ml solution (2 µg in 400 µl) in methanol. Hill配方 C₂₈H₄₀O₅ 化学配方 C₂₈H₄₀O₅ Molar Mass 456.6 可逆 N 结构配方图像 生物信息 主靶 nuclear export of LR-NES 主靶IC50 ≤ 1 ng/ml inhibiting proliferation and inducing cell cycle arrest at G1 phase 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 MeOH or aqueous buffers 储存和货运信息 货运代码 Dry Ice Only
毒性 Flammable
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 ≤ -70°C
避光 Protect from light
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). 包装信息 惰性气体下包装 Packaged under inert gas
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