merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2115,Anti-phospho-RSK4 Antibody (Ser372)

  • merck millipore,默克密理博,07-2115,Anti-phospho-RSK4 Antibody (Ser372)

    产品名称：Anti-phospho-RSK4 Antibody (Ser372)
    产品型号：07-2115
    This phospho-RSK4 antibody is validated for use in WB for the detection of the phospho-RSK4 protein.

    merck millipore,默克密理博,07-2115,Anti-phospho-RSK4 Antibody (Ser372)

  • 产品介绍
  • merck millipore,默克密理博,07-2115,Anti-phospho-RSK4 Antibody (Ser372)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2115
    描述 Anti-phospho-RSK4 Antibody (Ser372)
    Alternate Names
    • ribosomal protein S6 kinase, 90kDa, polypeptide 6
    • 90 kDa ribosomal protein S6 kinase 6
    • Ribosomal S6 kinase 4
    • S6K-alpha 6
    • p90-RSK 6
    • ribosomal protein S6 kinase polypeptide 6
    • ribosomal protein S6 kinase, 90kD, polypeptide 6
    背景信息 RSK1, RSK2, RSK3, and RSK4 (ribosomal protein S6 kinase, 90 kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases. Ribosomal S6-kinase 4 (RSK4) is thought to be mapped in the critical region that is commonly deleted in X-linked deafness type 3, mental retardation, and choroideremia. It may be involved in normal neuronal development. RSK4 is also thought to play a role in non-growth factor signaling and may also be important in tumor suppression.
    产品信息
    格式 Affinity Purified
    控制
    • EGF treated and untreated PC-12 cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This phospho-RSK4 antibody is validated for use in WB for the detection of the phospho-RSK4 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human RSK4 phosphorylated at Ser372.
    表位 Phosphorylated Ser372
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes RSK4 phosphorylated at Ser372.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • ">NP_055311
    Entrez基因汇总 This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways.
    基因符号
    • pp90RSK4
    • PP90RSK4
    • RSK-4
    • RSK4
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q9UK32
    UniProt汇总 FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

    COFACTOR: Magnesium (By similarity).

    ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues (By similarity).

    SUBUNIT STRUCTURE: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).

    PTM: Autophosphorylated on Ser-389, as part of the activation process (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

    Contains 1 AGC-kinase C-terminal domain.

    Contains 2 protein kinase domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in EGF treated and untreated PC-12 cell lysates.

    Western Blot Analysis: 2 µg/mL of this antibody detected RSK4 on 10 µg of EGF treated and untreated PC-12 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2115,Anti-phospho-RSK4 Antibody (Ser372)

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