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merck millipore,默克密理博,05-565,Anti-Nucleolin Antibody, clone 3G4B2
产品名称：Anti-Nucleolin Antibody, clone 3G4B2
产品型号：05-565
Anti-Nucleolin Antibody, clone 3G4B2 is a high quality Mouse Monoclonal Antibody for the detection of Nucleolin & has been validated in IP, WB, ICC.
merck millipore,默克密理博,05-565,Anti-Nucleolin Antibody, clone 3G4B2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, Ca, H ICC, WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 05-565 Replaces MABE466 品牌系列 Upstate
商名 - Upstate
描述 Anti-Nucleolin Antibody, clone 3G4B2 背景信息 Nucleolin, also known as C23, is the major nucleolar protein of exponentially growing eukaryotic cells. It is a ubiquitous conserved multi-domain phosphoprotein found in all vertebrate species. Nucleolin contains a specific bipartite nuclear localization signal sequence and three different structural domains. Nucleolin is a multifunctional protein involved in most steps of ribosome biogenesis. Nucleolin has been implicated in chromatin structure, rDNA transcription, rRNA maturation, ribosome assembly, cytokinesis, nucleogenesis, cell proliferation and growth, and
nucleo-cytoplasmic transport. Nucleolin also exhibits autodegradation, DNA and RNA helicase activities, and DNA-dependent ATPase activity. Nucleolin activities may be regulated by proteolysis, methylation, ADPribosylation, and phosphorylation by several kinases, including casein kinase II (CK2), p34cdc2, and protein kinase C-ζ.产品信息 格式 Culture Supernatant 控制 - HeLa nuclear extract
演示 mouse culture supernatant containing 0.05% sodium azide prior to the addition of glycerol to 30% 应用 应用 Anti-Nucleolin Antibody, clone 3G4B2 is a high quality Mouse Monoclonal Antibody for the detection of Nucleolin & has been validated in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Nuclear matrix extract from MDCK cells 克隆 clone 3G4B2 宿主 Mouse 特异性 nucleolin 同种型 IgG 品种反应性 MonkeyCanineHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005381
Entrez基因汇总 Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. 基因符号 - Nucleolin
- NCL
- FLJ45706
- nucleolin
- C23
纯化方法 Unpurified UniProt编号 - P19338
UniProt汇总 FUNCTION: SwissProt: P19338 # Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation.
SIZE: 710 amino acids; 76614 Da
SUBUNIT: Interacts with APTX and NSUN2. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat- SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.
SUBCELLULAR LOCATION: Nucleus, nucleolus.
SIMILARITY: SwissProt: P19338 ## Contains 4 RRM (RNA recognition motif) domains.产品使用声明 质量保证 routinely evaluated by immunoblot on HeLa nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µL
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