merck millipore,默克密理愽
  • merck millipore,默克密理博,16-284,Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate

  • merck millipore,默克密理博,16-284,Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate

    产品名称：Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate
    产品型号：16-284
    This Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate is validated for use in FC, IC, IF, WB for the detection of MAP Kinase 1/2 (Erk1/2).

    merck millipore,默克密理博,16-284,Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate

  • 产品介绍
  • merck millipore,默克密理博,16-284,Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Ch, H, MWB, FC, ICCRbAlexaFluor®555Polyclonal Antibody
    描述
    产品目录编号 16-284
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor® 555 conjugate
    Alternate Names
    • MAPK1/2, Extracellular signaling related kinase 1/2
    • MAPK1/2
    产品信息
    格式 AlexaFluor®555
    应用
    应用 This Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate is validated for use in FC, IC, IF, WB for the detection of MAP Kinase 1/2 (Erk1/2).
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunocytochemistry
    生物信息
    免疫原品种 38 residue synthetic peptide (CGG-PFTFDMELDDLPKERLKELIFQETARFQPGAPEAP) corresponding to the C-terminal 35 amino acids of the rat 44kDa MAP Kinase 2/Erk2 coupled to KLH. The immunizing sequence is totally conserved in Chinese hamster, is 34/35 identical in mouse, and 32/35 identical in human.
    宿主 Rabbit
    特异性 Recognizes MAPK1/Erk1, Mr 44kDa, and MAPK2/Erk2.
    同种型 IgG
    品种反应性 RatChickenHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_138957.2
    • NM_002745.4
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
    基因符号
    • ERK2
    • MAPK1
    • p40
    • PRKM2
    • MAPK2
    • PRKM1
    • p42-MAPK
    • p38
    • p41
    • ERK
    • ERK-2
    • ERT1
    • P42MAPK
    • p41mapk
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P28482
    UniProt汇总 FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).
    COFACTOR: Magnesium (By similarity).
    SIZE: 360 amino acids; 41390 Da
    SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.
    DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunocytochemistry and Flow Cytometry.
    使用声明
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at 4°C from date of shipment
    包装信息
    数量 50 µg

    merck millipore,默克密理博,16-284,Anti-MAP Kinase 1/2 (Erk1/2) Antibody, CT, Alexa Fluor 555 conjugate

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