merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2068,Anti-PRDM2 Antibody (RIZ1)

  • merck millipore,默克密理博,07-2068,Anti-PRDM2 Antibody (RIZ1)

    产品名称：Anti-PRDM2 Antibody (RIZ1)
    产品型号：07-2068
    Use Anti-PRDM2 (RIZ1) Antibody (Rabbit Polyclonal Antibody) validated in IHC, ELISA to detect PRDM2 (RIZ1) also known as GATA-3 binding protein G3B or Lysine N-methyltransferase 8.

    merck millipore,默克密理博,07-2068,Anti-PRDM2 Antibody (RIZ1)

  • 产品介绍
  • merck millipore,默克密理博,07-2068,Anti-PRDM2 Antibody (RIZ1)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISA, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2068
    描述 Anti-PRDM2 Antibody (RIZ1)
    Alternate Names
    • zinc-finger DNA-binding protein
    • GATA-3 binding protein G3B
    • GATA-3-binding protein G3B
    • Lysine N-methyltransferase 8
    • MTE-binding protein
    • PR domain containing 2, with ZNF domain
    • PR domain-containing protein 2
    • Retinoblastoma protein-interacting zinc finger protein
    • Zinc finger protein RIZ
    • retinoblastoma protein-binding zinc finger protein
    背景信息 PRDM2, also known as RIZ1, is a nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C- terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. RIZ1 is a tumor suppressor gene, and RIZ1 inactivation is commonly found in many types of human cancers. RIZ1 inactivation most frequently occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, or missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
    产品信息
    格式 Purified
    演示 Purified rabbit polyclonal in buffer containing 0.09% NaN3.
    应用
    应用 Use Anti-PRDM2 (RIZ1) Antibody (Rabbit Polyclonal Antibody) validated in IHC, ELISA to detect PRDM2 (RIZ1) also known as GATA-3 binding protein G3B or Lysine N-methyltransferase 8.
    主要应用
    • ELISA
    • Immunohistochemistry
    应用说明 ELISA:
    This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).
    生物信息
    免疫原品种 The immunogen was a KLH-conjugated synthetic peptide corresponding the C-terminal region of human PRDM2.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes PRDM2.
    品种反应性 Human
    Species Reactivity Note Human. Not tested in other species.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_0158662
    基因符号
    • OTTHUMP00000009687
    • RIZ
    • RIZ1
    • RIZ2
    • EC 2.1.1.43
    • HUMHOXY1
    • KMT8
    • MTB-ZF
    • OTTHUMP00000009642
    纯化方法 Protein G chromatography
    UniProt编号
    • Q13029
    UniProt汇总 FUNCTION: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.

    CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.

    SUBUNIT STRUCTURE:Binds to the retinoblastoma protein (RB). Interacts with GATA3.

    SUBCELLULAR LOCATION: Nucleus. Ref.6 Ref.1

    TISSUE SPECIFICITY: Highly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3.

    SEQUENCE SIMILARITY: Contains 8 C2H2-type zinc fingers.

    Contains 1 SET domain.
    产品使用声明
    质量保证 Immunohistochemistry:
    1:100 dilution of this antibody detected PRDM2 in formalin-fixed, paraffin-embedded human malignant melanoma tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-2068,Anti-PRDM2 Antibody (RIZ1)

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下一件merck millipore产品：merck millipore,默克密理博,373401,Hh/Gli Antagonist, GANT61 - CAS 500579-04-4 - Calbiochem


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