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  • merck millipore,默克密理博,07-178,Anti-Hox A9 Antibody

  • merck millipore,默克密理博,07-178,Anti-Hox A9 Antibody

    产品名称：Anti-Hox A9 Antibody
    产品型号：07-178
    Detect Hox A9 with Anti-Hox A9 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, WB, ICC.

    merck millipore,默克密理博,07-178,Anti-Hox A9 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-178,Anti-Hox A9 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, EMSA, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-178
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Hox A9 Antibody
    背景信息 HOXA9 is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa-9 markedly expands hematopoietic stem cells. HOXA9 expression changes dramatically with age - a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty.
    产品信息
    格式 Purified
    控制
    • Hoxa9 immortalized HF1 cells
    演示 Protein A purified immunoglobulin presented in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% Sodium Azide before the addition of glycerol to 30%.
    应用
    应用 Detect Hox A9 with Anti-Hox A9 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Electrophoretic Mobility Shift Assay
    • Western Blotting
    生物信息
    免疫原品种 GST fusion protein corresponding to residues 194-272 of mouse Hox A9
    宿主 Rabbit
    特异性 Hox A9
    同种型 IgG
    品种反应性 MouseHuman
    Species Reactivity Note Based on a BLAST search, the antibody will likely cross react with Newt, Coelacanth, Dog, Chicken, and Rat Hox A9; Antelope, Mouse and Guinea Pig Hox 1.7; Frog, human and Zebrafish Hox A-9B; and Kenyan Clawed Frog Hox B.1
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_152739
    Entrez基因汇总 In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.
    基因符号
    • ABD-B
    • HOXA9
    • MGC1934
    • Hox-1G
    • HOX1.7
    • HOX1G
    • HOX1
    纯化方法 Protein A chromatography
    UniProt编号
    • P31269
    UniProt汇总 FUNCTION: SwissProt: P31269 # Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
    SIZE: 272 amino acids; 30172 Da
    SUBCELLULAR LOCATION: Nucleus.
    DISEASE: SwissProt: P31269 # A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. & A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.
    SIMILARITY: SwissProt: P31269 ## Belongs to the Abd-B homeobox family. & Contains 1 homeobox DNA-binding domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on whole cell lysates of Hoxa9 immortalized HF1 myeloid progenitor cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-178,Anti-Hox A9 Antibody

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