merck millipore,默克密理博,08-126,Vitronectin, human recombinant

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merck millipore,默克密理博,08-126,Vitronectin, human recombinant
产品名称：Vitronectin, human recombinant
产品型号：08-126

merck millipore,默克密理博,08-126,Vitronectin, human recombinant

产品介绍

merck millipore,默克密理博,08-126,Vitronectin, human recombinant

重要规格表

主要应用
CULT

描述
产品目录编号	08-126
Replaces	CC080
品牌系列	Upstate
商名	Upstate
描述	Vitronectin, human recombinant

产品信息
演示	Liquid in 10mM Sodium Phosphate, pH 7.1, 150mM Sodium Chloride, 0.1mM DTT, 0.1mM PMSF and 50% glycerol.

应用
主要应用	Cell Culture

生物信息
浓缩	1.5 mg/mL
来源	N-terminal, GST-tagged, full-length human Vitronectin expressed in E. coli
品种	Human
Entrez基因编号	NM_000638.3
Entrez基因汇总	The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
基因符号	S-protein VTN VN epibolin V75 VNT
UniProt编号	P04004
UniProt汇总	FUNCTION: SwissProt: P04004 # Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. SIZE: 478 amino acids; 54306 Da SUBUNIT: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. SUBCELLULAR LOCATION: Secreted, extracellular space. TISSUE SPECIFICITY: Plasma. DOMAIN: SwissProt: P04004 The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. PTM: Sulfated on 2 tyrosine residues. & N- and O-glycosylated (By similarity). & Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. & It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SIMILARITY: Contains 4 hemopexin-like domains. & Contains 1 SMB (somatomedin-B) domain.

产品使用声明
质量保证	Routinely evaluated by cell adhesion assay.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -20°C from date of shipment

包装信息
数量	500 µg

merck millipore,默克密理博,08-126,Vitronectin, human recombinant

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