merck millipore,默克密理博,07-1490,Anti-Calcineurin Antibody

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,07-1490,Anti-Calcineurin Antibody
产品名称：Anti-Calcineurin Antibody
产品型号：07-1490
Detect Calcineurin using this Anti-Calcineurin Antibody validated for use in WB, IH(P) & IP.

merck millipore,默克密理博,07-1490,Anti-Calcineurin Antibody

产品介绍

merck millipore,默克密理博,07-1490,Anti-Calcineurin Antibody

Replacement Information
Replacement Information	07-1490 is a recommended replacement for AB1694.

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Ma, M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1490
Replaces	AB1694
描述	Anti-Calcineurin Antibody
背景信息	Calcineurin/PP2B is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin/PP2B has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin/PP2B's multifunctional capabilities in the regulation of calcium signaling.

产品信息
格式	Affinity Purified
控制	PC3 cell lysate
演示	Purified rabbit polyclonal IgG in buffer containing TBS and 40% glycerol as a cryopreservative.

应用
应用	Detect Calcineurin using this Anti-Calcineurin Antibody validated for use in WB, IH(P) & IP.
主要应用	Western Blotting
应用说明	Immunohistochemisty (paraffin): Representative testing from a previous lot. Calcineurin representative staining pattern/morphology in human vascular tissue. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoprecipitation: 3 μL per reaction of a previous lot of this antibody was used in Immunoprecipitation. Optimal working dilutions must be determined by end user

生物信息
免疫原品种	Purified bovine brain calcineurin.
宿主	Rabbit
特异性	Recognizes both the catalytic A and regulatory B subunits of calcineurin, a calcium- and calmodulin-dependent protein phosphatase.
同种型	IgG
品种反应性	MammalsMouseHuman
Species Reactivity Note	Human and Mouse. Broad reactivity with mammal species is expected.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_000944.3
基因符号	EC 3.1.3.16 PPP3CA CCN1 PPP2B CNA1 CAN CALNA1 CALN CALNA
纯化方法	Affinity Purfied
UniProt编号	Q08209
UniProt汇总	FUNCTION: SwissProt: Q08209 # Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1. COFACTOR: Binds 1 Fe(3+) ion per subunit. & Binds 1 zinc ion per subunit. SIZE: 521 amino acids; 58688 Da SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with MYOZ1, MYOZ2 and MYOZ3. SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). SIMILARITY: SwissProt: Q08209 ## Belongs to the PPP phosphatase family. PP-2B subfamily.

产品使用声明
质量保证	Routinely evaluated by Western Blot on PC3 lysates. Western Blot Analysis: 1:500 dilution of this lot detected PP2B B on 10 μg of PC3 lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen. Handling Recommendations: Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen.
Handling Recommendations: Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.