merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB343F,Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

  • merck millipore,默克密理博,FCMAB343F,Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

    产品名称：Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3
    产品型号：FCMAB343F
    Detect Integrin β4 using this Milli-Mark Anti-Integrin β4-FITC Antibody, clone ASC-3 validated for use in FC.

    merck millipore,默克密理博,FCMAB343F,Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

  • 产品介绍
  • merck millipore,默克密理博,FCMAB343F,Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB343F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3
    Alternate Names
    • CD104
    • Integrin beta-4
    • GP150
    背景信息 Integrin beta 4 is a glycoprotein which associates with the alpha 6 integrin to form the alpha 6/beta 4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.
    产品信息
    格式 FITC
    控制
    • A431 cells
    演示 Purified mouse monoclonal IgG1k conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Detect Integrin β4 using this Milli-Mark Anti-Integrin β4-FITC Antibody, clone ASC-3 validated for use in FC.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Human Squamous Cell Carcinoma Cells (SCC 9)
    克隆 ASC-3
    宿主 Mouse
    特异性 Antibody recognizes Integrin β4.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000204
    Entrez基因汇总 Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
    基因符号
    • GP150
    • ITGB4
    • CD104
    纯化方法 Protein A Purified
    UniProt编号
    • P16144
    UniProt汇总 FUNCTION: SwissProt: P16144 # Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.

    SIZE: 1822 amino acids; 202151 Da

    SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-4 associates with alpha-6.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICITY: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.

    DOMAIN: SwissProt: P16144 The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.

    DISEASE: SwissProt: P16144 # Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. & Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. This nonlethal form of junctional epidermolysis bullosa is characterized by life- long blistering of the skin, associated with hair and tooth abnormalities.

    SIMILARITY: Belongs to the integrin beta chain family. & Contains 1 Calx-beta domain. & Contains 4 fibronectin type-III domains. & Contains 1 VWFA domain.
    产品使用声明
    质量保证 Evaluated by flow cytometry using A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB343F,Milli-Mark™ Anti-Integrin β4-FITC Antibody, clone ASC-3

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