merck millipore,默克密理愽
  • merck millipore,默克密理博,07-104,Anti-IGF2 mRNA-binding protein 3 Antibody

  • merck millipore,默克密理博,07-104,Anti-IGF2 mRNA-binding protein 3 Antibody

    产品名称：Anti-IGF2 mRNA-binding protein 3 Antibody
    产品型号：07-104
    This Anti-IGF2 mRNA-binding protein 3 Antibody is validated for use in WB for the detection of IGF2 mRNA-binding protein 3.

    merck millipore,默克密理博,07-104,Anti-IGF2 mRNA-binding protein 3 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-104,Anti-IGF2 mRNA-binding protein 3 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Eq, H, M, Chp, CaWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-104
    描述 Anti-IGF2 mRNA-binding protein 3 Antibody
    Alternate Names
    • insulin-like growth factor 2 mRNA binding protein 3
    • IGF II mRNA binding protein 3
    • IGF-II mRNA-binding protein 3
    • IGF2 mRNA-binding protein 3
    • KH domain containing protein overexpressed in cancer
    • KH domain-containing protein overexpressed in cancer
    • VICKZ family member 3
    背景信息 The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
    产品信息
    格式 Affinity Purified
    控制
    • Hek293 cell lysate
    演示 Purified rabbit serum in PBS with 0.09% azide.
    应用
    应用 This Anti-IGF2 mRNA-binding protein 3 Antibody is validated for use in WB for the detection of IGF2 mRNA-binding protein 3.
    主要应用
    • Western Blotting
    应用说明 Western Blot (SNAP ID) Analysis: 2 µg/mL from a previous lot detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.

    Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human IGF2 mRNA-binding protein 3 at and around the C-terminus.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes IGF2 mRNA-binding protein 3 at the C-terminus.
    品种反应性 HorseHumanMouseChimpanzeeCanine
    Species Reactivity Note Reacts with human and mouse. Predicted to react with chimpanzee, Rhesus monkey, dog, and horse based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_006538
    Entrez基因汇总 The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor 2 leader 3 mRNA and may repress translation of insulin-like growth factor 2 during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq].
    基因符号
    • IGF2BP3
    • IMP-3
    • IMP3
    • KOC1
    • VICKZ3
    • hKOC
    纯化方法 Affinity Purfied
    UniProt编号
    • O00425
    UniProt汇总 FUNCTION: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.

    SUBUNIT STRUCTURE: Homodimer and multimer.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.

    TISSUE SPECIFICITY: Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

    INVOLVEMENT IN DISEASE: Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.

    SEQUENCE SIMILARITIES: Belongs to the RRM IMP/VICKZ family.

    Contains 4 KH domains.

    Contains 2 RRM (RNA recognition motif) domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in Hek293 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected IGF2 mRNA-binding protein 3 on 10 µg of Hek293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-104,Anti-IGF2 mRNA-binding protein 3 Antibody

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