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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-727 品牌系列 Upstate
商名 - Upstate
描述 Anti-FcεRI Antibody, γ subunit Alternate Names - immunoglobulin E receptor, high affinity, gamma chain
- Fc fragment of IgE, high affinity I, receptor for, gamma polypeptide
- Fc fragment of IgE, high affinity I, receptor for
- gamma<br />polypeptide
- Fc-epsilon RI-gamma
- FceRI gamma
- IgE Fc receptor subunit gamma
- FceRI gamma
- IgE Fc receptor subunit gamma
- immunoglobulin E receptor
- high affinity
背景信息 Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors. 产品信息 格式 Purified 控制 - RBL cell lysate
演示 Purified rabbit polylclonal IgG in buffer containing 70% storage buffer (0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide) and 30% glycerol. 应用 应用 This Anti-FcεRI Antibody, γ subunit is validated for use in WB, IP for the detection of FcεRI. 主要应用 - Western Blotting
应用说明 Immunoprecipitation: Reported to immunoprecipitate FcεR1, γ-subunit from RBL cells. 生物信息 免疫原品种 Synthetic peptide KHEKPPQ corresponding to amino acids 80-86 of γ-subunit of Fc receptors. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes and is specific for FcεRI, γ-subunit, MW 10kDa. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Human, rat and mouse. Other species cross-reactivity not tested. 抗体类型 Polyclonal Antibody Entrez基因汇总 The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated. 基因符号 - OTTHUMP00000063478
- FCER1G
纯化方法 Protein A purfied UniProt编号 - P30273
UniProt汇总 FUNCTION: SwissProt: P30273 # The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.
SIZE: 86 amino acids; 9667 Da
SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P30273 ## Belongs to the CD3Z/FCER1G family. & Contains 1 ITAM domain.产品使用声明 质量保证 Evaluated by western blot on RIPA lysate of RBL cells.
Western Blot Analysis: 0.5-2 μg/mL of this antibody detected FcεRI, γ-subunit in RIPA lysate of RBL cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at from date of receipt. 包装信息 数量 200 µg
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