merck millipore,默克密理博,07-1494,Anti-Calcineurin Bα Antibody

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merck millipore,默克密理博,07-1494,Anti-Calcineurin Bα Antibody
产品名称：Anti-Calcineurin Bα Antibody
产品型号：07-1494
Anti-Calcineurin Bα Antibody detects level of Calcineurin Bα & has been published & validated for use in WB, IH(P).

merck millipore,默克密理博,07-1494,Anti-Calcineurin Bα Antibody

产品介绍

merck millipore,默克密理博,07-1494,Anti-Calcineurin Bα Antibody

Replacement Information
Replacement Information	07-1494 is a recommended replacement for AB1699.

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Ma, H, M, R	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-1494
Replaces	AB1699
描述	Anti-Calcineurin Bα Antibody
Alternate Names	CnBalpha
背景信息	Calcineurin/PP2B is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin/PP2B has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin/PP2B's multifunctional capabilities in the regulation of calcium signaling.

产品信息
格式	Affinity Purified
控制	A431 cell lysate
演示	Purified rabbit polyclonal IgG in buffer containing TBS, 40% glycerol as a cryopreservative and no preservatives.

应用
应用	Anti-Calcineurin Bα Antibody detects level of Calcineurin Bα & has been published & validated for use in WB, IH(P).
主要应用	Western Blotting
应用说明	Immunohistochemisty (paraffin): Calcineurin Bα representative staining pattern/morphology in normal human placenta. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen here in nutrient rich erythrocytes for both mother and embryo blood. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide (KASYPLEMCSHFD) coupled to KLH.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	Specific for the Balpha isoform of the CnB regulatory subunit of calcineurin. CnBalpha is the predominant gene for the regulatory subunit of calcineurin in most tissues. CnBbeta is, a testis-enriched isoform. The antibody reacts with CnBalpha subunits of calcineurin of all mammalian species so far tested.
同种型	IgG
品种反应性	MammalsHumanMouseRat
Species Reactivity Note	Human, Mouse and Rat. Broad reactivity is expected for mammals.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_000945.3
基因符号	CNB1 PPP3R1 CALNB1 CNB CNA2
纯化方法	Affinity Purfied
UniProt编号	P63098
UniProt汇总	FUNCTION: SwissProt: P63098 # Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. SIZE: 170 amino acids; 19300 Da SUBUNIT: Composed of a catalytic subunit (A) and a regulatory subunit (B). SIMILARITY: SwissProt: P63098 ## Contains 4 EF-hand domains. MISCELLANEOUS: This protein has four functional calcium-binding sites.

产品使用声明
质量保证	Routinely evaluated by Western Blot on A431 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected Calcineurin Bα on 10 μg of A431 lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.