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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-647 品牌系列 Upstate
商名 - Upstate
描述 Anti-Flt-3 Antibody, cytoplasmic domain 产品信息 格式 Purified 演示 0.07M Tris-glycine, pH 7.4, 0.105M NaCl and 0.035% sodium azide, and 30% glycerol. 应用 应用 Anti-Flt-3 Antibody, cytoplasmic domain is an antibody against Flt-3 for use in IP, WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 His-tag fusion protein corresponding to residues 786-1000 of mouse Flt3 宿主 Rabbit 特异性 premature and the mature forms of Flt3 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_004119
Entrez基因汇总 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. 基因符号 - STK1
- FLT3
- STK-1
- CD135
- FLK2
- OTTHUMP00000042340
纯化方法 Protein A chromatography UniProt编号 - P36888
UniProt汇总 FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
SIZE: 993 amino acids; 112903 Da
SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Bone marrow cells.
SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from HeLa cells or mouse Bafl-3 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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