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品种反应性 主要应用 宿主 格式 抗体类型 Ox, H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1342 描述 Anti-NLRX1 (NOD9) Antibody Alternate Names - NOD-like receptor X1
- Nucleotide-binding oligomerization domain protein 26
- Nucleotide-binding oligomerization domain protein 5
- Nucleotide-binding oligomerization domain protein 9
- NLR family member X1
- NLR family, X12
- Caterpiller protein 11.3
背景信息 NLR family member X1 (NLRX1) belongs to the Nod-like receptor (NLR) family of proteins, a group of proteins characterized by their highly conserved nucleotide binding domain (NBD) and their leucine-rich-repeats (LRR). NLRX1 is the only member of this family localized to mitochondria, where it plays a role in antiviral signaling by blocking virus-induced interaction of RLH-MAVS, serving as a negative regulator of the antiviral responses mediated by MAVS. It also serves to up-regulate NF-Kappa-B and JNK-dependent signaling cascades as its overexpression induces reactive oxygen species (ROS). NLRX1 has been observed in high quantities within the heart, mammary gland, and muscle tissues. It has also been observed at the protein level in various cell lines including; JURKAT, HeLa, HL60, RAJI, THP-1, and 293T. 产品信息 格式 Affinity Purified 控制 - PC3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect NLRX1 (NOD9) using this Anti-NLRX1 (NOD9) Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human NLRX1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 0 品种反应性 OxHumanMouseRat Species Reactivity Note Demonstrated to react with human, mouse, and rat.
Predicted to react with ox based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_078894
Entrez基因汇总 This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq]. 基因符号 - DLNB26
- nlrx1
- NOD5
- NOD26
- NOD9
- CLR11.3
纯化方法 Affinity Purified UniProt编号 - Q86UT6
UniProt汇总 FUNCTION: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.
SUBUNIT STRUCTURE: Interacts with MAVS.
SUBCELLULAR LOCATION: Mitochondrion outer membrane
TISSUE SPECIFICTY: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
SEQUENCE SIMILARITIES: Belongs to the NLRP family.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
SEQUENCCE CAUTION: The sequence BAB15075.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAG51714.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG51714.1 differs from that shown. Reason: Erroneous termination at position 951. Translated as Trp.产品使用声明 质量保证 Evaluated by Western Blot in PC3 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected NLRX1 in 10 µg of PC3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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