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品种反应性 主要应用 宿主 格式 抗体类型 R, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-632 品牌系列 Upstate
商名 - Upstate
描述 Anti-NR2A Antibody Alternate Names - glutamate receptor, ionotropic, N-methyl D-aspartate 2A
- N-methyl D-aspartate receptor subtype 2A
- N-methyl-D-aspartate receptor channel, subunit epsilon-1
- N-methyl-D-aspartate receptor subunit 2A
- NMDA receptor subtype 2A
- NMDA receptor subtype 2A
- glutamate receptor
- ionotropic
背景信息 NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. 产品信息 格式 Purified 控制 - Brain tissue.
演示 Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. 应用 应用 Detect NR2A using this Anti-NR2A Antibody validated for use in IP & WB. 主要应用 - Western Blotting
应用说明 Immunoprecipitation:
4 µg of a previous lot immuno-precipitated NR2A from rat brain hippocampus membranes and rat brain microsomal preparations.生物信息 免疫原品种 6His-tagged fusion protein corresponding to amino acids 1265-1464 of mouse NMDA receptor 2A (NR2A). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes NR2A, MW ~170 kDa. 同种型 IgG 品种反应性 RatMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_008170
Entrez基因汇总 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). 基因符号 - NR2A
- GRIN2A
- hNR2A
- Glutamate
- NMDAR2A
纯化方法 Protein A purfied UniProt编号 - Q12879
UniProt汇总 FUNCTION: SwissProt: Q12879 # NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
SIZE: 1464 amino acids; 165283 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: Q12879 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 质量保证 Evaluated by western blot in rat brain microsomal preparations (Catalog # 12-144).
Western Blot Analysis:
0.5-2 µg/mL of this antibody detected NR2A in rat brain microsomal preparations (Catalog # 12-144).使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 200 µg
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