merck millipore,默克密理博,481908,Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 - CAS 658084-64-1

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Merck Millipore 默克密理愽

merck millipore,默克密理博,481908,Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 - CAS 658084-64-1 - Calbiochem

经验配方	CAS号
C₂₄H₂₉N₃O₂	658084-64-1

描述
概述	A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (K_i = 0.4 nM for the enzyme/substrate complex; K_i^′ = 0.3 nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10 nM vs no inhibition of NPRT activity at 1 µM in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD⁺ (Cat. Nos. 481911 & 481915) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10 nM FK866), likewise the addition of exogenous NAD⁺ is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD⁺-depletion and cell death.
产品目录编号	481908
品牌系列	Calbiochem®
同义词	(E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide, NAMPT Inhibitor, NAPRT Inhibitor, APO866, NAMPTase Inhibitor I, PBEF Inhibitor I, Visfatin Inhibitor I

参考
参考	Formentini, L., et al. 2009. Biochem. Pharmacol. 77, 1612. Nakahata, Y., et al. 2009. Science 324, 654. Ramsey. K.M., et al. 2009. Science 324, 651. Billington, R.A., et al. 2008. J. Biol. Chem. 283, 6367. Hasmann, M. and Schemainda, I., 2003. Cancer Res. 63, 7436.

产品信息
CAS号	658084-64-1
形式	Yellow liquid
配方	Supplied as a 50 mM (2 mg/102.17 µl) solution in DMSO.
Hill配方	C₂₄H₂₉N₃O₂
化学配方	C₂₄H₂₉N₃O₂
Molar Mass	391.5
结构配方图像

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,481908,Nicotinamide Phosphoribosyltransferase Inhibitor, FK866 - CAS 658084-64-1 - Calbiochem

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