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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15632 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Hey 2/HRT2 Antibody Alternate Names - hairy/enhancer-of-split
背景信息 This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined 产品信息 格式 Affinity Purified 控制 - human testis tissue lysate
演示 Purified in PBS with 0.05% NaN3 应用 应用 This Anti-Hey 2/HRT2 Antibody is validated for use in WB for the detection of Hey 2/HRT2. 主要应用 - Western Blotting
应用说明 Optimal working dilutions must be determined by the end user. 生物信息 免疫原品种 Synthetic Linear Peptide Toward C Terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Cat. # AB15632 recognizes Hey 2/HRT2 protein. 品种反应性 Human Species Reactivity Note Human. May react with pig, primate, horse, rat and mouse based on sequence homology. Reactivity with other species has not been determined. 抗体类型 Polyclonal Antibody Entrez基因汇总 This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. 基因符号 - HES2
- HEY2
- BHLHB2
- BHLHB3
- HES1
UniProt编号 - Q9UBP5
UniProt汇总 FUNCTION: SwissProt: Q9UBP5 # Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
SIZE: 337 amino acids; 35808 Da
SUBUNIT: May self-associate (By similarity). Interacts with GATA4, HES1 and HEYL (By similarity). Interacts with HDAC1, NCOR1 and SIN3A (By similarity). Interacts with ARNT and GATA6.
SUBCELLULAR LOCATION: Nucleus (By similarity).
DISEASE:SwissProt: Q9UBP5 # Defects in HEY2 may be involved in atrioventricular septal defects (AVSD).
SIMILARITY: SwissProt: Q9UBP5 ## Belongs to the HEY family. & Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 Orange domain.产品使用声明 质量保证 Routinely tested on human testis tissue lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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