merck millipore,默克密理愽
  • merck millipore,默克密理博,23-041,c-Cbl Protein, active, 10 µg

  • merck millipore,默克密理博,23-041,c-Cbl Protein, active, 10 µg

    产品名称：c-Cbl Protein, active, 10 µg
    产品型号：23-041
    Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

    merck millipore,默克密理博,23-041,c-Cbl Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,23-041,c-Cbl Protein, active, 10 µg

    重要规格表

    主要应用 品种 级联部件
    EAHumanE3
    描述
    产品目录编号 23-041
    品牌系列 Upstate
    商名
    • Upstate
    描述 c-Cbl Protein, active, 10 µg
    长描述 N-terminal GST-tagged, recombinant human c-Cbl full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose.
    Alternate Names
    • RNF55
    • E3 ubiquitin-protein ligase CBL
    • Casitas B-lineage lymphoma proto-oncogene
    • RING finger protein 55
    • Signal transduction protein CBL
    • CBL2
    背景信息 Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
    应用
    应用 Active, full length, recombinant human c-Cbl. N-terminal GST-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
    主要应用
    • Enzyme Assay
    生物信息
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    级联部件 E3
    Entrez基因编号
    • NM_005188 (GenBank Number)
    纯化方法 Purified using glutathione sepharose.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,23-041,c-Cbl Protein, active, 10 µg

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