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品种反应性 主要应用 宿主 格式 抗体类型 H IH(P) Rb Purified Polyclonal Antibody 描述 产品目录编号 06-018 描述 Anti-ROR2 Antibody, CT Alternate Names - tyrosine-protein kinase transmembrane receptor ROR2
- Neurotrophic tyrosine kinase, receptor-related 2
- neurotrophic tyrosine kinase receptor-related 2
- receptor tyrosine kinase-like orphan receptor 2
- receptor tyrosine kinase-like orphan receptor 2
背景信息 Receptor tyrosine kinase-like orphan receptor 2, also known as ROR2, is a member of the Tyr protein kinase family and ROR subfamily of cell surface receptors. Located in the transmembrane, ROR2 is highly expressed during early embryonic development and is associated with chondrocyte formation, cartilage and growth plate maturity. Expression levels of ROR2 subside after 16 days and occur minimally in adults. ROR2 is post translationaly modified by ATM or ATR phosphorylation when DNA damage occurs. Mutations in ROR2 result in brachydactyly type B1 (BDB1), characterized by either hypoplasia or aplasia of the distal phalanges and nails. ROR2 is also associated with recessive Robinow syndrome (RRS), resulting in shortening of limbs, facial dysmorphia and spinal defects. 产品信息 格式 Purified 控制 - Human gastric mucosa
演示 Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. 应用 应用 Anti-ROR2 Antibody, C-terminus detects level of ROR2 & has been published & validated for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
生物信息 免疫原品种 KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of ROR2 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminal region of ROR2. 品种反应性 Human Species Reactivity Note Human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004551.2
Entrez基因汇总 The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq].
基因符号 - OTTHUMP00000063680
- BDB
- BDB1
- EC 2.7.10.1
- MGC163394
- NTRKR2
- OTTHUMP00000021634
纯化方法 Protein G purfied UniProt编号 - Q01974
UniProt汇总 FUNCTION:Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development.
Catalytic activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Developmental stage Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7
DISEASE: Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) [MIM:113000]. BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed.
Defects in ROR2 are a cause of recessive Robinow syndrome (RRS) [MIM:268310]. RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. Ref.8 Ref.9
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Contains 1 FZ (frizzled) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 kringle domain.
Contains 1 protein kinase domain.
产品使用声明 质量保证 Evaluated by immunohistochemistry (paraffin) in human gastric mucosa.
Immunohistochemistry(paraffin): 1:50-1:200 dilution of this antibody detected ROR2 in human gastric mucosa.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
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