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merck millipore,默克密理博,07-582-I,Anti-phospho-IRF-3 (Ser396) Antibody
产品名称:Anti-phospho-IRF-3 (Ser396) Antibody
产品型号:07-582-I
Use Anti-phospho-IRF-3 (Ser396) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-IRF-3 (Ser396) also known as Interferon regulatory factor 3.
merck millipore,默克密理博,07-582-I,Anti-phospho-IRF-3 (Ser396) Antibody
- 产品介绍
- merck millipore,默克密理博,07-582-I,Anti-phospho-IRF-3 (Ser396) Antibody
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-582-I Replaces 07-582 描述 Anti-phospho-IRF-3 (Ser396) Antibody Alternate Names - IRF-3
- Interferon regulatory factor 3
背景信息 Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal serine and threonine residues (between 385 and 405) leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. 产品信息 格式 Affinity Purified 控制 - Untreated and sendai virus treated A549 cell lysates
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-phospho-IRF-3 (Ser396) Antibody (Rabbit Polyclonal Antibody) validated in WB to detect phospho-IRF-3 (Ser396) also known as Interferon regulatory factor 3. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human IRF-3 phosphorylated at Ser396. 表位 SNS → ANA: Mutation of this residue results in loss of viral-induced phosphorylation of IRF-3. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes IRF-3 phosphorylated at Ser396. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rhesus Macaque and Porcine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 -
">NP_001562
基因符号 - IRF3
纯化方法 Affinity purified UniProt编号 - Q14653
产品使用声明 质量保证 Evaluated by Western Blot in untreated and sendai virus treated A549 cell lysates.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected phospho-IRF-3 (Ser396) in 10 µg of sendai virus treated A549 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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