merck millipore,默克密理愽
  • merck millipore,默克密理博,324895,eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

  • merck millipore,默克密理博,324895,eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

    产品名称：eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem
    产品型号：324895
    The eIF-2α Inhibitor, Salubrinal, also referenced under CAS 304475-63-6, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,324895,eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324895,eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₁₇Cl₃N₄OS304475-63-6
    描述
    概述 A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 = ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 = ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. Also available as a 50 mM solution in DMSO (Cat. No. 324897).
    产品目录编号 324895
    品牌系列 Calbiochem®
    同义词 Sal
    参考
    参考 Boyce, M., et al. 2005. Science 307, 935.
    产品信息
    CAS号 304475-63-6
    具有ATP竞争性 N
    形式 Beige solid
    Hill配方 C₂₁H₁₇Cl₃N₄OS
    化学配方 C₂₁H₁₇Cl₃N₄OS
    Molar Mass 479.8
    可逆 N
    结构配方图像
    生物信息
    主靶 elF-2α
    主靶IC50 3 µM preventing HSV replication both in Vero cells.
    纯度 ≥90% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,324895,eIF-2α Inhibitor, Salubrinal - CAS 304475-63-6 - Calbiochem

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