merck millipore,默克密理愽
  • merck millipore,默克密理博,07-909,Anti-phospho-Src (Tyr418) Antibody

  • merck millipore,默克密理博,07-909,Anti-phospho-Src (Tyr418) Antibody

    产品名称：Anti-phospho-Src (Tyr418) Antibody
    产品型号：07-909
    Anti-phospho-Src (Tyr418) Antibody detects level of phospho-Src (Tyr418) & has been published & validated for use in IC, IH & WB.

    merck millipore,默克密理博,07-909,Anti-phospho-Src (Tyr418) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-909,Anti-phospho-Src (Tyr418) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, Ch, HWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-909
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Src (Tyr418) Antibody
    Alternate Names
    • c-Src, p60-Src Src kinase
    • c-Src
    产品信息
    格式 Affinity Purified
    控制
    • Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein
    演示 Affinity Purified rabbit polyclonal IgG in PBS (without Mg2+ and Ca2+), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol.
    应用
    应用 Anti-phospho-Src (Tyr418) Antibody detects level of phospho-Src (Tyr418) & has been published & validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Src (Tyr418) in RIPA lysate of Src transfected CEF cells.
    生物信息
    免疫原品种 Peptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418)
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Src phosphorylated on Tyrosine residue 418.
    同种型 IgG
    品种反应性 MouseChickenHuman
    Species Reactivity Note Predicted to cross-react with Rat and Frog (100% homologous) based on sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_198291.1
    • NM_005417.3
    Entrez基因汇总 This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
    基因符号
    • pp60c-src
    • SRC
    • ASV
    • c-src
    • p60-Src
    • SRC1
    • c-SRC
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P12931
    UniProt汇总 SIZE: 536 amino acids; 59835 Da
    SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
    PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
    SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-909,Anti-phospho-Src (Tyr418) Antibody

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