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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-699 品牌系列 Upstate
商名 - Upstate
描述 Anti-IRS1 Antibody, clone 1M92-7 产品信息 格式 Purified 演示 20mM NaPO4, pH 7.4, 125mM NaCl, 0.07% sodium azide before the addition of glycerol to 30% 应用 应用 Anti-IRS1 Antibody, clone 1M92-7 is an antibody against IRS1 for use in IC, IH & IP. 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Not recommended for WB. 生物信息 免疫原品种 Full length recombinant rat IRS-1 protein produced in baculovirus without tags 克隆 1M92-7 宿主 Mouse 特异性 IRS1 同种型 IgG1κ 品种反应性 RatMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005544
基因符号 - HIRS-1
- IRS1
- IRS-1
纯化方法 Protein G purfied UniProt编号 - P35568
UniProt汇总 FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
SIZE: 1242 amino acids; 131591 Da
SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.产品使用声明 质量保证 routinely evaluated by immunoprecipitating IRS-1 from 500mg of 3T3/A31 RIPA lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
上一件merck millipore产品：merck millipore,默克密理博,ST1703,Anti-DLL1 Mouse mAb (4F8)
下一件merck millipore产品：merck millipore,默克密理博,565953,Anti-Sialyl Lewis x Mouse mAb (KM93)
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