merck millipore,默克密理愽
  • merck millipore,默克密理博,05-590,Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

  • merck millipore,默克密理博,05-590,Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

    产品名称：Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12
    产品型号：05-590
    Detect phospho-STAT6 (Tyr641) also known as signal transducer & activator of transcription 6 with Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 (mouse monoclonal antibody), that has been demonstra More>>

    merck millipore,默克密理博,05-590,Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

  • 产品介绍
  • merck millipore,默克密理博,05-590,Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-590
    Replaces MAB3702
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12
    产品信息
    格式 Purified
    演示 100µg of lyophilized thiophilic and size exclusion chromatography purified mouse IgG1 from 1mL 2x PBS / 0.09 % Na-azide / PEG and Sucrose. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL. Store at -20°C.
    应用
    应用 Detect phospho-STAT6 (Tyr641) also known as signal transducer & activator of transcription 6 with Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 (mouse monoclonal antibody), that has been demonstrated to work in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Peptide corresponding to residues of human STAT6 (Tyr641); recognizes STAT6 phosphorylated on Tyrosine 641.
    克隆 clone 16E12
    宿主 Mouse
    特异性 phosphorylated STAT6
    同种型 IgG1
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003153
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
    基因符号
    • IL-4-STAT
    • STAT6
    • STAT6C
    • D12S1644
    • STAT6B
    修改
    • Phosphorylation
    纯化方法 Thiophilic adsoption and size exclusion chromatography
    UniProt编号
    • P42226
    UniProt汇总 FUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
    SIZE: 847 amino acids; 94135 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
    SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from IL4-stimulated HepG2 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-590,Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

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